Lindsey M. Lyle, MS, PA-C, of the University of Colorado Anschutz Medical Campus, discusses findings from a long-term follow-up of the combination of eprenetapopt and azacitidine in patients with TP53-mutant myelodysplastic syndromes (MDS) and oligoblastic acute myeloid leukemia (AML). This is especially important information for advanced practitioners, given the fact that these gene mutations are found in up to 20% of patients with MDS or AML and 30% to 40% of treatment-related MDS/AML cases, representing a distinct molecular cohort with poor outcomes (Abstract 246).

Lindsey M. Lyle, MS, PA-C, of the University of Colorado Anschutz Medical Campus, discusses results from a quality improvement initiative in which health-care professionals in two large hospital systems in the United States identified challenges in caring for patients with myeloproliferative neoplasms and learned to enhance their ability to deliver patient-centered care and improve team-based collaboration (Abstract 1911).

Sandra Kurtin, PhD, ANP-C, AOCN, of the University of Arizona Cancer Center, discusses a survey that provided insight into the wide range of advanced practice providers’ chemotherapy prescribing practices throughout the United States and the many discrepancies in privileges (Abstract 1897).

Sandra Kurtin, PhD, ANP-C, AOCN, of the University of Arizona Cancer Center, discusses results from a study that showed patients with lymphoma or chronic lymphocytic leukemia who have taken part in a clinical trial generally are more confident and more involved in their health-care decision-making, reporting having better conversations with their doctors compared to patients who have not participated in a clinical trial (Abstract 3047).

Lindsey M. Lyle, MS, PA-C, of the University of Colorado Anschutz Medical Campus, discusses phase III data from the PRINCE study, which showed that patients with paroxysmal nocturnal hemoglobinuria who were naive to complement-inhibitor treatment demonstrated meaningful hematologic and clinical improvements following 26 weeks of treatment with the monoclonal antibody pegcetacoplan (Abstract 606).

Kathryn Tyler Maples, PharmD, BCOP, of Winship Cancer Institute of Emory University, discusses data of key importance for advanced practitioners on patients with multiple myeloma who are heavily pretreated and predominantly triple-class refractory, and who relapse after receiving bispecific antibodies (BiAbs). These patients may still have good outcomes when sequentially treated with other immunologic or T-cell–directed therapeutics such as BiAbs and CAR-T cells (Abstract 821).

Kathryn Tyler Maples, PharmD, BCOP, of Winship Cancer Institute of Emory University, discusses findings from the MagnetisMM-1 trial on elranatamab, a humanized bispecific molecule that targets BCMA expressed in multiple myeloma and engages CD3 on T cells. The results, of interest to advanced practitioners, support continued development of elranatamab as a single agent and in combination with standard treatments for patients with relapsed or refractory multiple myeloma (Abstract 895).

Kathryn Tyler Maples, PharmD, BCOP, of Winship Cancer Institute of Emory University, discusses phase I/II findings from the MajesTEC-1 trial, which seems to confirm that teclistamab monotherapy induces deep and durable responses in heavily pretreated patients with relapsed or refractory multiple myeloma. Of note for advanced practitioners, this agent is a T-cell–redirecting, bispecific IgG4 antibody that targets both B-cell maturation antigen (BCMA) and CD3 receptors to induce the T-cell–mediated cytotoxicity of BCMA-expressing myeloma cells (Abstract 896).

Sandra Kurtin, PhD, ANP-C, AOCN, of the University of Arizona Cancer Center, discusses the largest reported analysis to date of patients with aggressive B-cell lymphoma who developed progressive disease after CAR T-cell therapy. This is of special interest to advanced practitioners, since there is little guidance on the optimal treatment approaches for these patients (Abstract 884).