Abstract
Pancreatic cancer is one of the most fatal cancers in the United States. Currently, it is the third leading cause of cancer-related deaths, and it is estimated that by 2030, it will be the second leading cause of cancer-related deaths behind lung cancer. It has poor overall survival rates, even with aggressive treatment. Quality of life is low in this patient population, due to poor prognosis at diagnosis and complex symptomatology. The purpose of this article is to explore the role of the advanced practitioner in the diagnosis, treatment, and symptom management of pancreatic cancer.
References
Chong, E., Crowe, L., Mentor, K., Pandanaboyana, S., & Sharp, L. (2023). Systematic review of caregiver burden, unmet needs, and quality-of-life among informal caregivers of patients with pancreatic cancer. Supportive Care in Cancer, 31(1), 74. https://doi.org/10.1007/s00520-022-07468-7
Chung, V., Sun, V., Ruel, N., Smith, T. J., & Ferrell, B. R. (2022). Improving palliative care and quality of life in pancreatic cancer patients. Journal of Palliative Medicine, 25(5), 720–727. https://doi.org/10.1089/jpm.2021.0187
Halbrook, C. J., Lyssiotis, C. A., di Magliano, M. P., & Maitra, A. (2023). Pancreatic cancer: Advances and challenges. Cell, 186(8), 1729–1754. https://doi.org/10.1016/j.cell.2020.02.014
Huang, J., Lok, V., Ngai, C. H., Zhang, L., Yuan, J., Lao, X.,…Wong, M. C. (2021). Worldwide burden of risk factors for, and trends in pancreatic cancer. Gastroenterology, 160(3), 744–754. https://doi.org/10.1053/j.gastro.2020.10.007
Idachaba, S., Dada, O., Abimbola, O., Olayinka, O., Uma, A., Oluna, E., & Fakoya, A. O. J. (2019). A review of pancreatic cancer: Epidemiology, genetics, screening, and management. Open Access Macedonian Journal of Medical Sciences, 7(4), 663. https://doi.org/10.3889/oamjms.2019.104
Jiang, S., Fagman, J. B., Ma, Y., Liu, J., Vihav, C., Engstrom, C.,…Chen, C. (2022). A comprehensive review of pancreatic cancer and its therapeutic challenges. Aging (Albany NY), 14(18), 7635. https://doi.org/10.18632/aging.204310
Kolbeinsson, H., Chandana, S., Wright, G., & Chung, M. (2023). Pancreatic cancer: A review of current treatment and novel therapies. Journal of Investigative Surgery, 36(1), 2129884. https://doi.org/10.1080/08941939.2022.2129884
Lohse, I., & Brothers, S. P. (2020). Pathogenesis and treatment of pancreatic cancer related pain. Anticancer, 40(4), 1789–1796. https://doi.org/10.21873/anticanres.14133
Lucas, A. L., & Kastrinos, F. (2019). Screening for pancreatic cancer. JAMA, 322(5), 407–408. https://doi.org/10.1001/jama.2019.9690
Luo, H., Galvao, D., Newton, R., Lopez, P., Tang, C., Fairman, C.,…Taaffe, D. R. (2021). Exercise medicine in the management of pancreatic cancer: A systematic review. Pancreas, 50(3), 280. https://doi.org/10.1097/MPA.0000000000001753
Michoglou, K., Ravinthiranathan, A., San Ti, S., Dolly, S., & Thillai, K. (2023). Pancreatic cancer and depression. World Journal of Clinical Cases, 11(12), 2631–2636. https://doi.org/10.12998/wjcc.v11.i12.2631
National Cancer Institute. (2024). Cancer stat facts: Pancreatic cancer. Surveillance, Epidemiology, and End Results Program Reports on Cancer. https://seer.cancer.gov/statistics/reports.html
Pihlak, R., Frizziero, M., Mak, S. Y. G., Nuttall, C., Lamarca, A., Hubner, R. A.,…McNamara, M. G. (2023). Relevant study: Patient and clinician perspectives on clinically-meaningful outcomes in advanced pancreatic cancer. Cancers, 15(3), 738. https://doi.org/10.3390/cancers15030738
Poulia, K. A., Antoniadou, D., Sarantis, P., & Karamouzis, M. V. (2022). Pancreatic cancer prognosis, malnutrition risk, and quality of life: A cross-sectional study. Nutrients, 14(3), 442. https://doi.org/10.3390/nu14030442
Raufi, A. G., May, M. S., Hadfield, M. J., Seyhan, A. A., & El-Deiry, W. S. (2023). Advances in liquid biopsy technology and implications for pancreatic cancer. International Journal of Molecular Sciences, 24(4), 4238. https://doi.org/10.3390/ijms24044238
Schepis, T., De Lucia, S. S., Pellegrino, A., Del Gaudio, A., Maresca, R., Coppola, G.,…Nista, E. C. (2023). State-of-the-art and upcoming innovations in pancreatic cancer care: A step forward to precision medicine. Cancers, 15(13), 3423. https://doi.org/10.3390/cancers15133423
Scott, E., & Jewell, A. (2019). Supportive care needs of people with pancreatic cancer: A literature review. Cancer Nursing Practice, 22(4). https://doi.org/10.7748/cnp.2019.e1566
Si, K., Xue, Y., Yu, X., Zhu, X., Li, Q., Gong, W.,…Duan, S. (2021). Fully end-to-end deep-learning-based diagnosis of pancreatic tumors. Theranostics, 11(4), 1982. https://doi.org/10.7150/thno.52508
Stoffel, E. M., Brand, R. E., & Goggins, M. (2023). Pancreatic cancer: Changing epidemiology and new approaches to risk assessment, early detection, and prevention. Gastroenterology, 164(5), 752–765. https://doi.org/10.1053/j.gastro.2023.02.012
Tang, C. C., Von Ah, D., & Fulton, J. S. (2018). The symptom experience of patients with advanced pancreatic cancer: An integrative review. Cancer Nursing, 41(1), 33–44. https://doi.org/10.1097/NCC.0000000000000463
Tonini, V., & Zanni, M. (2022). Early diagnosis of pancreatic cancer: What strategies to avoid a foretold catastrophe. World Journal of Gastroenterology, 28(31), 4235. https://doi.org/10.3748/wjg.v28.i31.4235